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Kalziumantagonisten

Warnhinweise und Vorsichtsmassnahmen: current use of calcium-channel blockers for 10 or more years was associated with higher risks of ductal breast cancer (odds ratio [OR], 2.4; 95% CI, 1.2-4.9) (P = .04 for trend) and lobular breast cancer (OR, 2.6; 95% CI, 1.3-5.3) (P = .01 for trend). This relationship did not vary appreciably by type of calcium-channel blocker used (short-acting vs long-acting, dihydropyridines vs non-dihydropyridines). In contrast, use of diuretics, β-blockers, and angiotensin II antagonists were not associated with risk (1).

Unerwünschte Wirkungen: Gingivahyperplasie (2).

Referenzen:
  1. Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years. JAMA Intern Med. 2013;173(17): 1629-1637: full text.
  2. Medically induced gingival hyperplasia. Mayo Clin Proc. 1998;73:1196-1199: full text | pdf.